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Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity

Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity

Authors :
Chapel, C
Garcia, C
Bartosch, B
Roingeard, P
Zitzmann, N
Cosset, F-L
Dubuisson, J
Dwek, RA
Trepo, C
Zoulim, F
Durantel, D
Publication Year :
2016
Publisher :
Elsevier, 2016.

Abstract

HCV morphogenesis is a key step of the viral cycle and represents an original target for the development of new antivirals that could complement more conventional antiviral strategies based on inhibition of viral enzymes. As proof of concept, the inhibition of morphogenesis was demonstrated using the BVDV, a pestivirus related to HCV, as a surrogate model. Using this model, it was shown that alpha-glucosidase inhibitors, i.e. deoxynojirimycin (DNJ) derivatives, could inhibit viral morphogenesis in cellulo via the perturbation of the N-glycosylation pathway. Due to the importance of N-glycosylation for HCV glycoprotein folding and assembly, it was hypothesized that such inhibitors could also affect HCV morphogenesis.

Subjects

Subjects :
virus diseases

Details

Database :
OpenAIRE
Accession number :
edsair.dedup.wf.001..99317e457ab3097f4dd76a4365178334