Back to Search
Start Over
Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction
- Source :
- Scopus-Elsevier, Circulation Research, 95(11), e85-95. Lippincott Williams and Wilkins, van der Velden, J, Merkus, D, Klarenbeek, B R, James, A T, Boontje, N M, Dekkers, D H, Stienen, G J, Lamers, J M & Duncker, D J 2004, ' Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. ', Circulation Research, vol. 95, no. 11, pp. e85-95 .
-
Abstract
- Myocardial infarction (MI) initiates cardiac remodeling, depresses pump function, and predisposes to heart failure. This study was designed to identify early alterations in Ca2+ handling and myofilament proteins, which may contribute to contractile dysfunction and reduced beta-adrenergic responsiveness in postinfarct remodeled myocardium. Protein composition and contractile function of skinned cardiomyocytes were studied in remote, noninfarcted left ventricular (LV) subendocardium from pigs 3 weeks after MI caused by permanent left circumflex artery (LCx) ligation and in sham-operated pigs. LCx ligation induced a 19% increase in LV weight, a 69% increase in LV end-diastolic area, and a decrease in ejection fraction from 54+/-5% to 35+/-4% (all P
- Subjects :
- cardiovascular system
Subjects
Details
- ISSN :
- 15244571
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Circulation Research, 95(11), e85-95. Lippincott Williams and Wilkins, van der Velden, J, Merkus, D, Klarenbeek, B R, James, A T, Boontje, N M, Dekkers, D H, Stienen, G J, Lamers, J M & Duncker, D J 2004, ' Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. ', Circulation Research, vol. 95, no. 11, pp. e85-95 .
- Accession number :
- edsair.dedup.wf.001..97094805f6cbfce7dc3dab62d4de42b2