Back to Search Start Over

Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction

Authors :
Velden, J.
Daphne Merkus
Klarenbeek, B. R.
James, A. T.
Boontje, N. M.
Dekkers, D. H.
Stienen, G. J.
Lamers, J. M.
Duncker, D. J.
Physiology
ICaR - Heartfailure and pulmonary arterial hypertension
Surgery
Source :
Scopus-Elsevier, Circulation Research, 95(11), e85-95. Lippincott Williams and Wilkins, van der Velden, J, Merkus, D, Klarenbeek, B R, James, A T, Boontje, N M, Dekkers, D H, Stienen, G J, Lamers, J M & Duncker, D J 2004, ' Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. ', Circulation Research, vol. 95, no. 11, pp. e85-95 .

Abstract

Myocardial infarction (MI) initiates cardiac remodeling, depresses pump function, and predisposes to heart failure. This study was designed to identify early alterations in Ca2+ handling and myofilament proteins, which may contribute to contractile dysfunction and reduced beta-adrenergic responsiveness in postinfarct remodeled myocardium. Protein composition and contractile function of skinned cardiomyocytes were studied in remote, noninfarcted left ventricular (LV) subendocardium from pigs 3 weeks after MI caused by permanent left circumflex artery (LCx) ligation and in sham-operated pigs. LCx ligation induced a 19% increase in LV weight, a 69% increase in LV end-diastolic area, and a decrease in ejection fraction from 54+/-5% to 35+/-4% (all P

Subjects

Subjects :
cardiovascular system

Details

ISSN :
15244571
Database :
OpenAIRE
Journal :
Scopus-Elsevier, Circulation Research, 95(11), e85-95. Lippincott Williams and Wilkins, van der Velden, J, Merkus, D, Klarenbeek, B R, James, A T, Boontje, N M, Dekkers, D H, Stienen, G J, Lamers, J M & Duncker, D J 2004, ' Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. ', Circulation Research, vol. 95, no. 11, pp. e85-95 .
Accession number :
edsair.dedup.wf.001..97094805f6cbfce7dc3dab62d4de42b2