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Measurement of serum marker for bone metastasis (1-CTP) in hepatobiliary and pancreas malignancies

Authors :
Nanashima, A.
Takeshita, H.
Tobinaga, S.
Araki, M.
Sumida, Y.
Kunizaki, M.
Tanaka, K.
Abo, T.
Hidaka, S.
Terumitsu Sawai
Yasutake, T.
Nagayasu, T.
Source :
Scopus-Elsevier
Publication Year :
2010
Publisher :
Thieme, 2010.

Abstract

Background/Aims: Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (1CTP) is a sensitive serum marker for metastatic bone carcinomas and may also be associated with invasiveness of various carcinomas. To clarify the significance of 1CTP in hepato-biliary pancreas malignancies, we examined the relationship between clinicopathological features and serum level of 1CTP. Methodology: The subjects were 75 patients who underwent surgical resections including 27 patients with liver carcinomas, 15 with extra-hepatic biliary carcinomas, 14 pancreatic carcinomas and 19 benign diseases. Results: 1CTP level tended to be higher in the malignant diseases than in benign diseases but this difference was not significant (p=0.065). Compared to benign adenoma, 1CTP level in the malignant diseases was significantly higher (p=0.049). 1CTP level tended to be higher in patients with cholangitis compared to those with no inflammation or benign tumors (p=0.065). 1CTP was not correlated with any tumor markers. 1CTP was not associated with node status and vascular infiltrations. 1CTP level tended to be lower in patients with poor differentiation. Conclusions: Serum level of 1CTP might be a predictive marker for hepatobiliary pancreas malignancies but also reflects the degree of co-existing cholangitis.<br />Hepato-Gastroenterology, 57(101), pp.694-697; 2010

Details

Language :
English
ISSN :
01726390
Volume :
57
Issue :
101
Database :
OpenAIRE
Journal :
Hepato-Gastroenterology
Accession number :
edsair.dedup.wf.001..8ff1bc698bdc93aa23ab96df42354e20