Back to Search
Start Over
Mendelian randomisation study of smoking exposure in relation to breast cancer risk
- Source :
- British journal of cancer, vol 125, iss 8
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- BackgroundDespite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk.MethodsWe applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.ResultsGenetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10-2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect.ConclusionOur MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
- Subjects :
- Genotyping Techniques
Oncology and Carcinogenesis
ABCTB Investigators
Breast Neoplasms
NBCS Collaborators
Cigarette Smoking
Substance Misuse
Clinical Research
Breast Cancer
Tobacco
Genetics
Humans
2.1 Biological and endogenous factors
Genetic Predisposition to Disease
Oncology & Carcinogenesis
Polymorphism
Aetiology
Cancer
Tobacco Smoke and Health
Prevention
Human Genome
Substance Abuse
Genetic Pleiotropy
Single Nucleotide
Mendelian Randomization Analysis
Good Health and Well Being
Case-Control Studies
Public Health and Health Services
kConFab Investigators
Female
Drug Abuse (NIDA only)
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- British journal of cancer, vol 125, iss 8
- Accession number :
- edsair.dedup.wf.001..82e579825164d627410b6292f23a5803