Back to Search
Start Over
Chromium treatment has no effect in patients with type 2 diabetes in a Western population: A randomized, double-blind, placebo-controlled trial
- Source :
- Diabetes Care, 30(5), 1092-1096. AMER DIABETES ASSOC, Diabetes Care, 30(5), 1092-6. AMER DIABETES ASSOC
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE - Chromium treatment has been reported to improve glycemic control in patients with type 2 diabetes. However, concern exists about the possible toxic effects of chromium picolinate. The aim of this study was to determine the effect of chromium treatment in the form of chromium yeast on glycemic control in a Western population of patients with type 2 diabetes who were being treated with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS - In this 6-month, double-blind study, patients with moderate glycemic control, being treated with oral hypoglycemic agents, were randomly assigned to receive either a placebo or treatment with 400 mu g of chromium daily in the form of chromium yeast. The primary efficacy parameter was a change in A1C. Secondary end points were changes in lipid profile, BMI, blood pressure, body fat, and insulin resistance. RESULTS - No differences were found for the change in A1C between the intervention and placebo groups, nor were any differences found between the groups for the secondary end points. CONCLUSIONS - There is no evidence that chromium in the form of chromium yeast is effective in improving glycemic control in Western patients with type 2 diabetes who are taking oral hypoglycemic agents.
- Subjects :
- Male
Diabetes Mellitus, Type 2/drug therapy
IMPROVE GLUCOSE
Glycated Hemoglobin A/metabolism
Lipids/blood
INSULIN SENSITIVITY
Chromium/therapeutic use
Reproducibility of Results
PICOLINATE
HAMSTER OVARY CELLS
BREWERS-YEAST
Middle Aged
BLOOD-LIPIDS
SUPPLEMENTATION
Placebos
Treatment Outcome
Double-Blind Method
CARDIOVASCULAR-DISEASE
ELDERLY SUBJECTS
Humans
Female
GLUCOSE-TOLERANCE
Aged
Netherlands
Subjects
Details
- Language :
- English
- ISSN :
- 19355548 and 01495992
- Database :
- OpenAIRE
- Journal :
- Diabetes Care, 30(5), 1092-1096. AMER DIABETES ASSOC, Diabetes Care, 30(5), 1092-6. AMER DIABETES ASSOC
- Accession number :
- edsair.dedup.wf.001..8221532935ba810adae06237e4d36eb1