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BCL10 expression and localization in Ocular Adnexa MALT lymphomas: A comparative cytogenetic and immunohistochemical study

BCL10 expression and localization in Ocular Adnexa MALT lymphomas: A comparative cytogenetic and immunohistochemical study

Authors :
Margherita Cerrone
Collina, F.
Chiara, A.
Corazzelli, G.
Pia Curcio, M.
Renzo, A.
Russo, F.
Cantile, M.
Staibano, S.
Strianese, D.
Tranfa, F.
Botti, G.
Rosa, G.
Franco, R.
Cerrone, Margherita
Collina, Francesca
De Chiara, Anna
Corazzelli, Gaetano
Pia Curcio, Maria
De Renzo, Amalia
Russo, Filippo
Cantile, Monica
Staibano, Stefania
Strianese, Diego
Tranfa, Fausto
Botti, Gerardo
De Rosa, Gaetano
Franco, Renato
Cerrone, M
Collina, F
De Chiara, A
Corazzelli, G
Curcio, Mp
De Renzo, A
Russo, F
Cantile, M
Strianese, D
Botti, G
De Rosa, G
Franco, R.
Source :
Scopus-Elsevier, DIGITUM. Depósito Digital Institucional de la Universidad de Murcia, instname, Europe PubMed Central

Abstract

Summary. T(1;14) (p22;q32) involving BCL10 and IGH genes is a rare but recurrent chromosomal aberration in MALT-type lymphoma. It is rarely described in ocular adnexa B cell lymphomas, although nuclear BCL10 shuttling seems to be critical for disease progression in this district. We have evaluated the translocations MALT lymphoma-related in a series of 45 ocular adnexa cases, focusing in particular on their relation with BCL10 expression and its cellular topographic distribution. A prognostic tissue microarray (TMA) with ocular adnexa MALT lymphomas was designed. A study of BCL10 expression and its topographic distribution was performed through immunohistochemistry. In addition the assessment of t(14;18) (q32;q21), t(1;14) (p22;q32) and t(11;18) (q21;q21) was determined by Fluorescent In Situ Hybridization (FISH). Our series revealed t(14;18) (q32;q21) in 6/43 cases (14,3%). t(1;14) (p22;q32), never described in ocular adnexa MALT lymphomas, was observed in 3/31 (9,7%), two of which exhibited the gain of 3’ upstream BCL10 gene signal (4%), whereas no case showed t(11;18) (q21;q21). Moreover, BCL10 expression was observed in 18/45 cases. In particular its nuclear expression was revealed in 12/45 cases, cytoplasmic expression in 5/45 and both cytoplasmic and nuclear expression in 1/45. Statistical analysis demonstrated that while BCL10 cytoplasmic expression is significantly related to the presence of the investigated chromosomal aberrations, in particular with t(14;18) (q32;q21), BCL10 nuclear shuttling does not show any correlation with these translocations. Our data support that BCL10 nuclear distribution is neither related to BCL10 rearrangement nor to other known translocations.

Details

Database :
OpenAIRE
Journal :
Scopus-Elsevier, DIGITUM. Depósito Digital Institucional de la Universidad de Murcia, instname, Europe PubMed Central
Accession number :
edsair.dedup.wf.001..82101c0d97abe008e882fa98d4d6a796