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Ultra-fast separations of pharmaceutical compounds with 10 mm columns packed with sub-2 μm particles
- Source :
- Scopus-Elsevier, LCGC Europe, Vol. 21, No 10 (2008) pp. 488-501
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Abstract
- Very short columns filled with 1.9 μm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anaesthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized Chromatographie system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.
- Subjects :
- ddc:615
Subjects
Details
- ISSN :
- 14716577
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, LCGC Europe, Vol. 21, No 10 (2008) pp. 488-501
- Accession number :
- edsair.dedup.wf.001..769a30ba2933f3e5fc0a645c178257da