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Kolageni elastin u jetri štakora otrovanih živinim kloridom

Authors :
Krystyna Olczyk
Kucharz, E. J.
Wieczorek, M.
Szczebara, M.
Sonecki, P.
Source :
Arhiv za higijenu rada i toksikologiju, Volume 41, Issue 1, Scopus-Elsevier
Publication Year :
1990
Publisher :
Institute for Medical Research and Occupational Health, 1990.

Abstract

Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. The increase was associated with elevated serum aminotransferase and alkaline phosphatase activities, and decreased total protein level in serum. Inflammatory changes were found in the liver. An increase in the fibrous protein content suggests that inflammatory reaction to mercuric chloride can result in hepatic fibrosis.<br />Trovanje štakora živinim kloridom (0,5 mg Hg/kg tjelesne težine na dan tijekom deset tjedana) imalo je za rezultat povećan sadržaj topljivog i netopljivog kolagena i elastina u jetri. Povećanje je dovedeno u vezu s povišenim aktivnostima aminotransferaze i alkalne fosfataze u serumu, i sa smanjenim nivoom ukupnog proteina u serumu. U jetri su zamijećene upalne promjene. Povišen sadržaj vlaknastog proteina upućuje na to da upalna reakcija na živin klorid može dovesti do fibroze jetre.

Details

Language :
English
ISSN :
18486312 and 00041254
Volume :
41
Issue :
1
Database :
OpenAIRE
Journal :
Arhiv za higijenu rada i toksikologiju
Accession number :
edsair.dedup.wf.001..6f1f4cf0ba4345156a27494c7d601d55