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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise
- Source :
- Cell, vol 181, iss 7
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
- Subjects :
- Adult
Male
Adolescent
Molecular Transducers of Physical Activity Consortium
Prevention
Evaluation of treatments and therapeutic interventions
Middle Aged
Biological Sciences
Cardiovascular
Medical and Health Sciences
Young Adult
Good Health and Well Being
Oxygen Consumption
Research Design
Physical Endurance
Animals
Humans
Female
Child
Exercise
6.7 Physical
Developmental Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cell, vol 181, iss 7
- Accession number :
- edsair.dedup.wf.001..6bde781bd0614e67686b14dc9d1ff737