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From Specific γ‐CD/[Nb 6 Cl 12 (H 2 O) 6 ] 2+ Recognition to Biological Activity Tuning
- Source :
- Chemistry-A European Journal, Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (33), pp.7479-7485. ⟨10.1002/chem.202000739⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
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Abstract
- International audience; Specific molecular recognition of γ-cyclodextrin (γ-CD) toward cationic hexanuclear niobium [Nb6Cl12(H2O)6] 2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ-CD} 2+. NMR, ITC and ESI-MS techniques were used to study the interaction between the inorganic cluster and the organic macrocycle in water. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6] 2+ , decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of composition, but crystallization by slow evaporation in air produces a 1:2 host-guest complex [Nb6Cl12(H2O)6@(γ-CD)2]Cl2·20H2O showing a cluster unit encapsulated between two molecules of γ-CD. The 1:2 complex was isolated and characterized by XRD, EA, IR and TGA. Quantum chemical calculations were performed to model host-guest interaction.
- Subjects :
- [CHIM]Chemical Sciences
Subjects
Details
- Language :
- English
- ISSN :
- 09476539 and 15213765
- Database :
- OpenAIRE
- Journal :
- Chemistry-A European Journal, Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (33), pp.7479-7485. ⟨10.1002/chem.202000739⟩
- Accession number :
- edsair.dedup.wf.001..66709cf62b9155ebcea18047b77dc16c