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Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial
- Source :
- Kelbaek, H, Kløvgaard, L, Helqvist, S, Lassen, J F, Krusell, L R, Engstrøm, T, Bøtker, H E, Jørgensen, E, Saunamäki, K, Aljabbari, S, Thayssen, P, Galløe, A, Jensen, G V H & Thuesen, L 2008, ' Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial. ', Journal of the American College of Cardiology, vol. 51, no. 21, pp. 2011-6 . https://doi.org/10.1016/j.jacc.2008.01.056, Kelbaek, H, Kløvgaard, L, Helqvist, S, Lassen, J F, Krusell, L R, Engstrøm, T, Bøtker, H E, Jørgensen, E, Saunamäki, K, Aljabbari, S, Thayssen, P, Galløe, A, Jensen, G V H & Thuesen, L 2008, ' Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions : 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial ', Journal of the American College of Cardiology, vol. 51, no. 21, pp. 2011-2016 . https://doi.org/10.1016/j.jacc.2008.01.056
- Publication Year :
- 2008
-
Abstract
- Udgivelsesdato: 2008-May-27 OBJECTIVES: Our purpose was to evaluate the long-term use of sirolimus-eluting stents (SES) and bare-metal stents (BMS) in patients with complex coronary artery lesions. BACKGROUND: Although the use of SES has proved to be effective in patients with simple coronary artery lesions, there are limited data of the long-term outcome of patients with complex coronary artery lesions. METHODS: We randomly assigned 322 patients with total coronary occlusions or lesions located in bifurcations, ostial, or angulated segments of the coronary arteries to have SES or BMS implanted. RESULTS: At 3 years, major adverse cardiac events had occurred in 20 patients (12%) in the SES group and in 59 patients (38%) in the BMS group (p < 0.001). Four versus 2 patients suffered a cardiac death (p = NS), and 5 versus 1 died of a noncardiac disease (p = NS) in the SES versus the BMS group. Six patients in the SES group versus 15 patients in the BMS group suffered a myocardial infarction (p < 0.05) during the 3-year observation period, and target lesion revascularization was performed in 8 patients (4.9%) versus 53 patients (33.8%), respectively (p < 0.001); of these, 4 in the SES versus 7 in the BMS group were performed between 1 and 3 years after the index treatment (p = NS). According to revised definitions, stent thrombosis occurred in 5 patients (3.1%) in the SES group and in 7 patients (4.4%) in the BMS group (p = NS); very late stent thrombosis was observed in 4 versus 1 patient. CONCLUSIONS: A continued benefit was observed up to 3 years after implantation of SES in patients with complex coronary artery lesions. The rate of late adverse events was similar in the 2 groups, and stent thromboses occurred rarely after 1 year. (Sirolimus Eluting Stents in Complex Coronary Lesions [SCANDSTENT]; NCT00151658)
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Kelbaek, H, Kløvgaard, L, Helqvist, S, Lassen, J F, Krusell, L R, Engstrøm, T, Bøtker, H E, Jørgensen, E, Saunamäki, K, Aljabbari, S, Thayssen, P, Galløe, A, Jensen, G V H & Thuesen, L 2008, ' Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial. ', Journal of the American College of Cardiology, vol. 51, no. 21, pp. 2011-6 . https://doi.org/10.1016/j.jacc.2008.01.056, Kelbaek, H, Kløvgaard, L, Helqvist, S, Lassen, J F, Krusell, L R, Engstrøm, T, Bøtker, H E, Jørgensen, E, Saunamäki, K, Aljabbari, S, Thayssen, P, Galløe, A, Jensen, G V H & Thuesen, L 2008, ' Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions : 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial ', Journal of the American College of Cardiology, vol. 51, no. 21, pp. 2011-2016 . https://doi.org/10.1016/j.jacc.2008.01.056
- Accession number :
- edsair.dedup.wf.001..61cbfda9f3489e06b19faddf1e07cdaf