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Hair cortisol concentrations and perceived stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder
- Source :
- Brandt, J M, Hemager, N, Ellersgaard, D, Gregersen, M, Søndergaard, A, Ohland, J, Søborg Spang, K, Christiani, C, Burton, B K, Greve, A, Hjorthøj, C, Mors, O, Plessen, K J, Møllegaard Jepsen, J R, Nordentoft, M & Elgaard Thorup, A A 2023, ' Hair cortisol concentrations and perceived stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder ', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 125, 110750 . https://doi.org/10.1016/j.pnpbp.2023.110750, Brandt, J M, Hemager, N, Ellersgaard, D, Gregersen, M, Søndergaard, A, Ohland, J, Spang, K S, Christiani, C, Burton, B K, Greve, A, Hjorthøj, C, Mors, O, Plessen, K J, Jepsen, J R M, Nordentoft, M & Thorup, A A E 2023, ' Hair cortisol concentrations and perceived stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder ', Progress in Neuro-Psychopharmacology & Biological Psychiatry, pp. 110750 . https://doi.org/10.1016/j.pnpbp.2023.110750
- Publication Year :
- 2023
-
Abstract
- BACKGROUND: Dysregulation of the HPA-axis, perceived stress and interpersonal trauma are associated with an elevated risk for schizophrenia and bipolar disorder. Being at familial high-risk of these two mental disorders also constitutes an increased risk. In this study, we aimed to investigate hair cortisol concentrations and perceived stress among 7-year-old children at familial high-risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls (controls).METHODS: A total of 515 children (mean age 7.8, SD 0.2) from baseline assessment of the Danish High Risk and Resilience Study - VIA 7 participated in this study. Hair cortisol concentrations were analyzed among 322 children (FHR-SZ; N = 111, FHR-BP; N = 82, controls; N = 129). Perceived stress was assessed with the Daily Life Stressor Scale including 512 children (FHR-SZ; N = 195, FHR-BP; N = 118, controls; N = 199). Interpersonal trauma was measured with face-to-face interviews.RESULTS: Seven-year-old children at FHR-SZ or FHR-BP did not have a higher level of hair cortisol concentrations compared with controls (FHR-SZ: mean: 5.10, 95%CI 3.69-6.52; FHR-BP: mean: 5.01, 95%CI 3.27-6.72; controls: mean: 4.51, 95%CI 3.61-5.40; p = 0.77). Self-reported perceived stress was higher among children at FHR-SZ and FHR-BP compared with controls (FHR-SZ: mean: 12.09, 95%CI 10.99-13.19; FHR-BP: mean: 10.69, 95%CI 9.38-11.99; controls: mean: 8.90, 95%CI 8.13-9.68; p CONCLUSIONS: Children at FHR-SZ and FHR-BP did not exhibit higher levels of hair cortisol concentrations at age 7, while both FHR-groups had higher level of self-reported perceived stress compared with controls. Early attention to stress in children at FHR is crucial and these vulnerabilities should be targeted in future interventions studies.
- Subjects :
- Bipolar disorder
Hair cortisol
Schizophrenia
Perceived stress
Familial high-risk
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brandt, J M, Hemager, N, Ellersgaard, D, Gregersen, M, Søndergaard, A, Ohland, J, Søborg Spang, K, Christiani, C, Burton, B K, Greve, A, Hjorthøj, C, Mors, O, Plessen, K J, Møllegaard Jepsen, J R, Nordentoft, M & Elgaard Thorup, A A 2023, ' Hair cortisol concentrations and perceived stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder ', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 125, 110750 . https://doi.org/10.1016/j.pnpbp.2023.110750, Brandt, J M, Hemager, N, Ellersgaard, D, Gregersen, M, Søndergaard, A, Ohland, J, Spang, K S, Christiani, C, Burton, B K, Greve, A, Hjorthøj, C, Mors, O, Plessen, K J, Jepsen, J R M, Nordentoft, M & Thorup, A A E 2023, ' Hair cortisol concentrations and perceived stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder ', Progress in Neuro-Psychopharmacology & Biological Psychiatry, pp. 110750 . https://doi.org/10.1016/j.pnpbp.2023.110750
- Accession number :
- edsair.dedup.wf.001..5b05c14733121fe858dbd43b33663df7