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[Neurotoxicity in mice due to cysteine-rich parts of visna virus and HIV-1 Tat proteins]

Authors :
Gourdou, I
Mabrouk, K
Harkiss, G
Marchot, P
Watt, N
Hery, F
Vigne, R
Centre National de la Recherche Scientifique (CNRS)
Source :
Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1990, 311 (4), pp.149-55
Publication Year :
1990
Publisher :
HAL CCSD, 1990.

Abstract

International audience; The trans-activating visna virus and HIV-1 Tat proteins share, at their amino-acid sequence level, a significant 60% analogy on 17 consecutive residues. These homologous sequences are also found in a part of the short neurotoxin sequence from snake venom. Synthetic peptides representative of the two analogous viral sequences are, after intracerebroventricular injection at doses of 200 micrograms per 20 g mouse, responsible for the death of the injected animal in few hours. The HIV-1 recombinant Tat protein has the same effect. Such observation suggests a direct role of the Tat lentiviral protein in the origin of the neurologic effects associated with visna and HIV-1 infections.

Details

Language :
French
Database :
OpenAIRE
Journal :
Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1990, 311 (4), pp.149-55
Accession number :
edsair.dedup.wf.001..5a12f0d0ff331bcd1d4b31a7c09e15fe