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Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy
- Source :
- Bulletin du Cancer, Bulletin du Cancer, John Libbey Eurotext, 2005, 92 (2), pp.E25-E30, Scopus-Elsevier
- Publication Year :
- 2005
- Publisher :
- HAL CCSD, 2005.
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Abstract
- International audience; This study determined the prevalence and the prognostic value of the expression of microtubule components in tumors of 19 patients with non small cell lung cancer receiving taxane-based regimens. Patient samples were stained with antibodies directed against total β tubulin, classes I, II and III β tubulin isotypes, δ2 alpha tubulin, τ protein, and the P-gp protein involved in the classical multidrug resistance phenotype. All tumors were stained with pan-β tubulin antibody and class I tubulin isotype. A majority of the tumor samples expressed class II and class III, although the percentage of positive cells varied significantly between tumors. δ2 alpha tubulin, τ protein and Pgp protein were found in only one tumor sample each. Progression-free survival was shorter (41 days) in patients whose tumors expressed high levels of class III tubulin isotype in comparison to patients with low levels (288 days, p = 0.02). There were 2 responses to chemotherapy among 9 patients (22%) with high levels of class III tubulin vs. 6 among 10 patients (60%) with low levels of expression (Fisher exact test: p = 0.11). These data suggest that high expression of class III tubulin by tumor cells is associated with poor prognosis in patients with NSCLC receiving a taxane-based regimen.
Details
- Language :
- English
- ISSN :
- 00074551 and 17696917
- Database :
- OpenAIRE
- Journal :
- Bulletin du Cancer, Bulletin du Cancer, John Libbey Eurotext, 2005, 92 (2), pp.E25-E30, Scopus-Elsevier
- Accession number :
- edsair.dedup.wf.001..593a276eaddee31e01d69c0b8159a3c7