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Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients

Authors :
Zafari, P.
Mostafaei, S.
Iranshahi, N.
Cyrus Jalili
Taghadosi, M.
Source :
Scopus-Elsevier, مجله علمی دانشگاه علوم پزشکی کردستان, Vol 22, Iss 6, Pp 40-48 (2018)

Abstract

Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of vitamin D plasma level with Foxp3 gene expression in the patients with RA. Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of vitamin D were measured by competitive ELISA method. Foxp3 gene expression was also determined by using realtime PCR technique. Results: The expression of Foxp3 gene was significantly lower in RA patients compared to that in the healthy controls (p

Details

Database :
OpenAIRE
Journal :
Scopus-Elsevier, مجله علمی دانشگاه علوم پزشکی کردستان, Vol 22, Iss 6, Pp 40-48 (2018)
Accession number :
edsair.dedup.wf.001..57d27927b5f338b349d3e8c193b61465