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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
- Source :
- Cordell, H J, Han, Y, Mells, G F, Li, Y, Hirschfield, G M, Greene, C S, Xie, G, Juran, B D, Zhu, D, Qian, D C, Floyd, J A B, Morley, K I, Prati, D, Lleo, A, Cusi, D, Gershwin, M E, Anderson, C A, Lazaridis, K N, Invernizzi, P, Seldin, M F, Sandford, R N, Amos, C I, Siminovitch, K A & Srirajaskanthan, R 2015, ' International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways ', Nature Communications, vol. 6, 8019 . https://doi.org/10.1038/ncomms9019
- Publication Year :
- 2015
-
Abstract
- Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cordell, H J, Han, Y, Mells, G F, Li, Y, Hirschfield, G M, Greene, C S, Xie, G, Juran, B D, Zhu, D, Qian, D C, Floyd, J A B, Morley, K I, Prati, D, Lleo, A, Cusi, D, Gershwin, M E, Anderson, C A, Lazaridis, K N, Invernizzi, P, Seldin, M F, Sandford, R N, Amos, C I, Siminovitch, K A & Srirajaskanthan, R 2015, ' International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways ', Nature Communications, vol. 6, 8019 . https://doi.org/10.1038/ncomms9019
- Accession number :
- edsair.dedup.wf.001..50cc8ceb5d58fc5957589bd37004421e
- Full Text :
- https://doi.org/10.1038/ncomms9019