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Advances in tissue engineering through stem cell-based co-culture
- Source :
- Journal of tissue engineering and regenerative medicine, vol 9, iss 5, Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, JC; & Athanasiou, KA. (2015). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 488-503. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0h521096, Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, J; & Athanasiou, KA. (2014). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/59n521v4, Journal of Tissue Engineering and Regenerative Medicine, vol 9, iss 5
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- © 2014 John Wiley & Sons, Ltd. Stem cells are the future in tissue engineering and regeneration. In a co-culture, stem cells not only provide a target cell source with multipotent differentiation capacity, but can also act as assisting cells that promote tissue homeostasis, metabolism, growth and repair. Their incorporation into co-culture systems seems to be important in the creation of complex tissues or organs. In this review, critical aspects of stem cell use in co-culture systems are discussed. Direct and indirect co-culture methodologies used in tissue engineering are described, along with various characteristics of cellular interactions in these systems. Direct cell-cell contact, cell-extracellular matrix interaction and signalling via soluble factors are presented. The advantages of stem cell co-culture strategies and their applications in tissue engineering and regenerative medicine are portrayed through specific examples for several tissues, including orthopaedic soft tissues, bone, heart, vasculature, lung, kidney, liver and nerve. A concise review of the progress and the lessons learned are provided, with a focus on recent developments and their implications. It is hoped that knowledge developed from one tissue can be translated to other tissues. Finally, we address challenges in tissue engineering and regenerative medicine that can potentially be overcome via employing strategies for stem cell co-culture use.
- Subjects :
- 1.1 Normal biological development and functioning
Clinical Sciences
Medical Physiology
Cell Culture Techniques
Biomedical Engineering
regenerative medicine
Bioengineering
Bone and Bones
Mice
Underpinning research
stem cells
Stem Cell Research - Nonembryonic - Human
Cell Adhesion
Animals
Humans
indirect co-culture
Transplantation
Tissue Engineering
5.2 Cellular and gene therapies
Cell Differentiation
Stem Cell Research
co-culture
Coculture Techniques
Extracellular Matrix
direct co-culture
Generic Health Relevance
repair
cellular interaction
Stem Cell Research - Nonembryonic - Non-Human
Development of treatments and therapeutic interventions
Signal Transduction
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of tissue engineering and regenerative medicine, vol 9, iss 5, Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, JC; & Athanasiou, KA. (2015). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 488-503. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0h521096, Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, J; & Athanasiou, KA. (2014). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/59n521v4, Journal of Tissue Engineering and Regenerative Medicine, vol 9, iss 5
- Accession number :
- edsair.dedup.wf.001..406907f6ef17c71bb4bb7a535831a124