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25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC)
- Source :
- Suderman, M J, Stene, L C, Bohlin, J, Page, C M, Holvik, K, Parr, C L, Magnus, M C, Siri, E H, Joubert, B R, Wu, M C, London, S J, Relton, C L & Nystad, W 2016, ' 25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) ', Journal of Steroid Biochemistry and Molecular Biology, vol. 159, pp. 102-109 . https://doi.org/10.1016/j.jsbmb.2016.03.005
- Publication Year :
- 2016
-
Abstract
- The aim of the study was to investigate whether maternal mid-pregnancy 25-hydroxyvitamin D concentrations are associated with cord blood DNA methylation.DNA methylation was assessed using the Illumina HumanMethylation450 BeadChip, and maternal plasma 25-hydroxyvitamin D was measured in 819 mothers/newborn pairs participating in the Norwegian Mother and Child Cohort (MoBa) and 597 mothers/newborn pairs participating in the Avon Longitudinal Study of Parents and Children (ALSPAC).Across 473,731CpG DNA methylation sites in cord blood DNA, none were strongly associated with maternal 25-hydroxyvitamin D after adjusting for multiple tests (false discovery rate (FDR) > 0.5; 473,731 tests). A meta-analysis of the results from both cohorts, using the Fisher method for combining p-values, also did not strengthen findings (FDR > 0.2). Further exploration of a set of CpG sites in the proximity of four a priori defined candidate genes (CYP24A1, CYP27B1, CYP27A1 and CYP2R1) did not result in any associations with FDR
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Suderman, M J, Stene, L C, Bohlin, J, Page, C M, Holvik, K, Parr, C L, Magnus, M C, Siri, E H, Joubert, B R, Wu, M C, London, S J, Relton, C L & Nystad, W 2016, ' 25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) ', Journal of Steroid Biochemistry and Molecular Biology, vol. 159, pp. 102-109 . https://doi.org/10.1016/j.jsbmb.2016.03.005
- Accession number :
- edsair.dedup.wf.001..3746d59f34159fa5d2e20391530e73aa