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Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI)
- Source :
- Magnetic resonance in medicine, vol 80, iss 5, Harris, RJ; Yao, J; Chakhoyan, A; Raymond, C; Leu, K; Liau, LM; et al.(2018). Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI). MAGNETIC RESONANCE IN MEDICINE, 80(5), 1962-1978. doi: 10.1002/mrm.27204. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5wn372jw
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- PURPOSE:To introduce a new pH-sensitive and oxygen-sensitive MRI technique using amine proton CEST echo spin-and-gradient echo (SAGE) EPI (CEST-SAGE-EPI). METHODS:pH-weighting was obtained using CEST estimations of magnetization transfer ratio asymmetry (MTRasym ) at 3 ppm, and oxygen-weighting was obtained using R2' measurements. Glutamine concentration, pH, and relaxation rates were varied in phantoms to validate simulations and estimate relaxation rates. The values of MTRasym and R2' in normal-appearing white matter, T2 hyperintensity, contrast enhancement, and macroscopic necrosis were measured in 47 gliomas. RESULTS:Simulation and phantom results confirmed an increase in MTRasym with decreasing pH. The CEST-SAGE-EPI estimates of R2 , R2*, and R2' varied linearly with gadolinium diethylenetriamine penta-acetic acid concentration (R2 = 6.2 mM-1 ·sec-1 and R2* = 6.9 mM-1 ·sec-1 ). The CEST-SAGE-EPI and Carr-Purcell-Meiboom-Gill estimates of R2 (R2 = 0.9943) and multi-echo gradient-echo estimates of R2* (R2 = 0.9727) were highly correlated. T2 lesions had lower R2' and higher MTRasym compared with normal-appearing white matter, suggesting lower hypoxia and high acidity, whereas contrast-enhancement tumor regions had elevated R2' and MTRasym , indicating high hypoxia and acidity. CONCLUSION:The CEST-SAGE-EPI technique provides simultaneous pH-sensitive and oxygen-sensitive image contrasts for evaluation of the brain tumor microenvironment. Advantages include fast whole-brain acquisition, in-line B0 correction, and simultaneous estimation of CEST effects, R2 , R2*, and R2' at 3 T.
- Subjects :
- Adult
Male
Biomedical Engineering
SAGE
Phantoms
Imaging
Young Adult
Computer-Assisted
Clinical Research
glioma
80 and over
Humans
Image Interpretation
Aged
Cancer
pH-weighted MRI
Brain Neoplasms
Echo-Planar Imaging
hypoxia
Neurosciences
Brain
Hydrogen-Ion Concentration
Middle Aged
Magnetic Resonance Imaging
Oxygen
Nuclear Medicine & Medical Imaging
Biomedical Imaging
Female
CEST
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Magnetic resonance in medicine, vol 80, iss 5, Harris, RJ; Yao, J; Chakhoyan, A; Raymond, C; Leu, K; Liau, LM; et al.(2018). Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI). MAGNETIC RESONANCE IN MEDICINE, 80(5), 1962-1978. doi: 10.1002/mrm.27204. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5wn372jw
- Accession number :
- edsair.dedup.wf.001..36b86b28e5f1fa64164c3ccd92018148
- Full Text :
- https://doi.org/10.1002/mrm.27204.