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α thalassaemia in British people
- Source :
- British Medical Journal. 290(6478)
- Publication Year :
- 1985
-
Abstract
- Although α thalassaemia is rare in north Europeans, it has been identified in British people with no known foreign ancestry. Twelve such patients were studied, of whom eight shared a distinctive molecular defect, which was clearly different from defects seen in subjects of Mediterranean or South East Asian origin. A rare but specific form of α thalassaemia is therefore present in the British population. In addition, two patients from families of mixed racial origin were encountered who had a moderately severe form of thalassaemia (HbH disease) due to the inheritance of one form of α thalassaemia from the British parent and another type from the foreign parent. This shows the importance of careful genetic counselling of British patients with haematological findings of thalassaemia.
Details
- Language :
- English
- ISSN :
- 09598146
- Volume :
- 290
- Issue :
- 6478
- Database :
- OpenAIRE
- Journal :
- British Medical Journal
- Accession number :
- edsair.dedup.wf.001..2977891674b9d43ca36b1fcc5bcaf644