Impact of Guideline adherence on outcome in Candidemia : Results from the ECMM Candida III multinational European study

Objectives: The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk factors, treatment, and outcomes of culture proven candidemia across Europe in order to assess how adherence to guideline recommendations correlate with outcome Methods: Each participating hospital included the first ~10 culture proven IC cases after 01-Jul-18 and entered data into the ECMM Candida III database on the FungiScope™ platform. EQUAL Candida Scores reflecting adherence to Guideline recommendations were assessed. Results: A total of 632 Candidemia cases were included from 64 institutions in 20 European countries. Overall mortality was 45% (286/632), and hospital stay was prolonged (median 2 days), for completion of parenteral therapy only, in 16% (100/621) of patients. EQUAL Candida Score was evaluable for 589 cases with candidemia. Candida scores correlated significantly with duration of hospitalization (r = 0.442; p