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Olfactory neuromodulation of motion vision circuitry in drosophila
- Source :
- Wasserman, SM; Aptekar, JW; Lu, P; Nguyen, J; Wang, AL; Keles, MF; et al.(2015). Olfactory neuromodulation of motion vision circuitry in drosophila. Current Biology, 25(4), 467-472. doi: 10.1016/j.cub.2014.12.012. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4xb2w4ct, Current biology : CB, vol 25, iss 4
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- © 2015 Elsevier Ltd All rights reserved. It is well established that perception is largely multisensory [1]; often served by modalities such as touch, vision, and hearing that detect stimuli emanating from a common point in space [2, 3]; and processed by brain tissue maps that are spatially aligned [4]. However, the neural interactions among modalities that share no spatial stimulus domain yet are essential for robust perception within noisy environments remain uncharacterized. Drosophila melanogaster makes its living navigating food odor plumes. Odor acts to increase the strength of gaze-stabilizing optomotor reflexes [5] to keep the animal aligned within an invisible plume, facilitating odor localization in free flight [6-8]. Here, we investigate the cellular mechanism for cross-modal behavioral interactions. We characterize a wide-field motion-selective interneuron of the lobula plate that shares anatomical and physiological similarities with the "Hx" neuron identified in larger flies [9, 10]. Drosophila Hx exhibits cross-modal enhancement of visual responses by paired odor, and presynaptic inputs to the lobula plate are required for behavioral odor tracking but are not themselves the target of odor modulation, nor is the neighboring wide-field "HSE" neuron [11]. Octopaminergic neurons mediating increased visual responses upon flight initiation [12] also show odor-evoked calcium modulations and form connections with Hx dendrites. Finally, restoring synaptic vesicle trafficking within the octopaminergic neurons of animals carrying a null mutation for all aminergic signaling [13] is sufficient to restore odor-tracking behavior. These results are the first to demonstrate cellular mechanisms underlying visual-olfactory integration required for odor localization in fruit flies, which may be representative of adaptive multisensory interactions across taxa.
- Subjects :
- Neurotransmitter Agents
Agricultural and Biological Sciences(all)
genetic structures
Biochemistry, Genetics and Molecular Biology(all)
1.1 Normal biological development and functioning
Psychology and Cognitive Sciences
Neurosciences
Biological Sciences
Olfactory Perception
Basic Behavioral and Social Science
Medical and Health Sciences
Random Allocation
Drosophila melanogaster
Underpinning research
Odorants
Behavioral and Social Science
Neurological
Visual Perception
Animals
Female
Eye Disease and Disorders of Vision
psychological phenomena and processes
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Wasserman, SM; Aptekar, JW; Lu, P; Nguyen, J; Wang, AL; Keles, MF; et al.(2015). Olfactory neuromodulation of motion vision circuitry in drosophila. Current Biology, 25(4), 467-472. doi: 10.1016/j.cub.2014.12.012. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4xb2w4ct, Current biology : CB, vol 25, iss 4
- Accession number :
- edsair.dedup.wf.001..2482623d9681486c25dfd300a1c5eebd