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Human T-lymphotropic virus type 1 and type 2 seroprevalence, incidence, and residual transfusion risk among blood donors in Brazil during 2007-2009
- Source :
- AIDS research and human retroviruses, vol 28, iss 10
- Publication Year :
- 2012
- Publisher :
- eScholarship, University of California, 2012.
-
Abstract
- Human T-lymphotropic virus type 1/2 (HTLV-1/2) infection is endemic in Brazil but representative donor prevalence and incidence data are lacking. All blood donations (2007-2009) from three blood centers in Brazil were studied. Samples reactive on one HTLV screening test (EIA) were retested with a different EIA; dual EIA reactivity correlated strongly with a confirmatory Western blot. Prevalence, incidence, and residual transfusion risk were calculated. Among 281,760 first-time donors, 363 were positive for HTLV on both EIAs (135 per 10(5), 95% CI 122-150). Prevalence differed considerably by region, from 83 to 222 per 10(5). Overall incidence rate was 3.6/10(5) person-years and residual transfusion risk was 5.0/10(6) per blood unit transfused. The logistic regression model showed significant associations with: age [adjusted odds ratio (aOR)=5.23 for age 50+ vs.
- Subjects :
- Adult
Male
Adolescent
NHLBI Retrovirus Epidemiology Donor Study-II (Reds-II)
Clinical Sciences
Blood Donors
Donor Selection
Immunoenzyme Techniques
Young Adult
Rare Diseases
Risk Factors
Virology
Prevalence
2.2 Factors relating to the physical environment
Humans
Mass Screening
Blood Transfusion
Aetiology
International Component
Incidence
Transfusion Reaction
Middle Aged
HTLV-I Infections
HTLV-I Antibodies
HTLV-II Antibodies
HTLV-II Infections
Female
Infection
Sentinel Surveillance
Brazil
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- AIDS research and human retroviruses, vol 28, iss 10
- Accession number :
- edsair.dedup.wf.001..1f6573acddb39c30e744b2e317659dda