Back to Search Start Over

Nanocolumnar coatings on implants exhibiting antibacterial properties

Authors :
González Sagardoy, María Ujué
Medina Cruz, David
Izquierdo-Barba, Isabel
Álvarez, Rafael
Fernández Castro, Marcial
Tien-Street, William
Vernet Crua, Ada
Muñoz-Piña, Sandra
Garcia-Valenzuela, Aurelio
Rico, Víctor J.
Arcos, Daniel
Fernández-Martínez, Iván
Palmero, Alberto
González-Elipe, Agustín R.
Vallet-Regí, María
Webster, Thomas J.
García-Martín, José Miguel
Ministerio de Economía y Competitividad (España)
Fundación Domingo Martínez
Fulbright Commission
Source :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Publication Year :
2020

Abstract

Trabajo presentado en la 2nd International Conference on Nanomaterials Applied to Life Sciences 2020 (NALS 2020), celebrada en Madrid (España), del 29 al 31 de enero de 2020<br />Addressing the problem of infection from the very first stage, i.e. inhibiting the formation of the bacterial biofilm, is a crucial step to prevent implant rejection. Nanocolumnar coatings exhibiting antibacterial properties have been fabricated by oblique deposition with magnetron sputtering [1]. The formation of nanocolumns (Fig.1) is the result of the effects of atomic shadowing when the atoms reach the surface along an inclined direction [2]. This technique is environmentally friendly: it is carried out at RT and does not involve chemical products (no recycling problems). Such methodology have been tested in a semiindustrial scale reactor, successfully coating in a single step the two sides of fixation plates for bone fractures [3]. Several in vitro experiments have been performed: analysis of bacterial adhesion and biofilm formation, analysis of osteoblast proliferation and mitochondrial activity, and osteoblasts–bacteria competitive growth scenarios, the latter also named “Race for the Surface” competition. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation [1,3]. Moreover, they are effective against Gram positive (S. aureus) and Gram negative (E. coli) bacteria [4]. Finally, when a synergic route is followed and the coatings are functionalized with Te nanorods, the antibacterial properties are enhanced, since Te adds contact-killing (Fig. 2), i.e. bactericidal effect, whilst the biocompatibility is preserved [4].<br />MINECO and Fundación Domingo Martínez for funding. J.M.G.-M. thanks the Fulbright Commission

Details

Database :
OpenAIRE
Journal :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Accession number :
edsair.dedup.wf.001..1e897ff5a79a67fa8626eb8422a0a28b