Využití neseparačních průtokových metod ve farmaceutické analýze

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Ivana Šrámková Supervisor: Assoc. Prof. Hana Sklenářová, Ph.D. Supervisor specialist: Burkhard Horstkotte, Ph.D. Title of the Dissertation Thesis: Application of non-separation flow techniques in pharmaceutical analysis Flow techniques are a branch of instrumental techniques in chemical analysis based on the handling of the sample in a tubing manifold. Since the introduction of what is recognized nowadays as modern flow techniques in the early seventies, this analytical approach gained popularity among scientist thanks to their main principles. Controlled dispersion and precise timing due to the programming enable full automation of a variety of analytical procedures. Flow methods were employed in a multiple different applications: simple sample measurement, chemical reactions, kinetic studies, sample pretreatment, separation, and others in an automated way. They are especially valued for automation, decrease of chemicals consumption and thus lower cost and waste production, and shortening of the analysis time. This dissertation presents new contributions to the field of flow techniques. It is divided into a theoretical part and an experimental part, the latter one listing five...