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Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- Source :
- The Journal of allergy and clinical immunology, vol 136, iss 3
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- Group 2 innate lymphoid cells (ILC2s) produce high levels of IL-5 and IL-13, both of which are important pathogenic mediators in eosinophilic esophagitis (EoE). ILC2s have not been previously described in EoE. Our study demonstrates the novel finding that ILC2s are increased in esophageal biopsies from EoE patients with active disease compared with inactive EoE and non-diseased controls, implicating these cells in EoE pathogenesis.
- Subjects :
- Adolescent
Allergy
Prostaglandin
Biopsy
Primary Cell Culture
Immunology
Immunophenotyping
Esophagus
Immunologic
Receptors
Humans
Innate
Lymphocyte Count
Antigens
Child
Preschool
Interleukin-13
Immunity
Infant
Eosinophilic Esophagitis
Interleukin-33
Lymphocyte Subsets
CD
Eosinophils
Gene Expression Regulation
Cytokines
Female
Interleukin-5
Signal Transduction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- The Journal of allergy and clinical immunology, vol 136, iss 3
- Accession number :
- edsair.dedup.wf.001..1596fb7bd91179c74c59fc2e4d634f94