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Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barre syndrome
- Source :
- Journal of Neuroimmunology, 182(1-2), 177. Elsevier
- Publication Year :
- 2007
-
Abstract
- The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain–Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1- specific IgA activated leukocytes through the IgA receptor, FcαRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS. © 2006 Elsevier B.V. All rights reserved. Keywords: Guillain–Barré syndrome; Autoantibodies; Pathogenicity; Gangliosides; FcγR
Details
- Language :
- English
- ISSN :
- 01655728
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology, 182(1-2), 177. Elsevier
- Accession number :
- edsair.dedup.wf.001..1096a8f8900743342f0bf42f4e17c9be