Inspired Sinewave technique to non-invasive lung function testing an introduction and update of recent developments

Inspired Sinewave is a novel technique to measure dead space, alveolar volume, and pulmonary blood flow noninvasively. In this paper, we describe a brief introduction to the principle of the technique, which involves forcing inspired concentrations to oscillate sinusoidally and measuring responding expired concentrations. Then, we give some updates to the recent developments of the device. These include accuracy and robustness studies of the device on bench lungs and volunteers, and study of lung volume change from sitting to supine. The success of these studies is a big step forward to make this novel device a useful clinical tool. The paper concludes with a description of future work.