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Towards a simple marker of hepato-visceral adiposity and insulin resistance: The Z-score change from weight-at-birth to BMI-in-childhood
- Source :
- PEDIATRIC OBESITY, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
- Publication Year :
- 2019
- Publisher :
- WILEY-BLACKWELL, 2019.
-
Abstract
- BACKGROUND: Insulin resistance and hepato-visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche/pubarche and puberty/menarche; this earlier timing in turn relates often to a mismatch between prenatal and postnatal weight gain, which can be estimated by calculating the Z-score change from birth weight (BW) to body mass index (BMI) in childhood. METHODS: We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato-visceral adiposity in prepuberty by reappraising a cohort of children (mean age, 8.5 years), born appropriate- (AGA, n = 41) or small-for-gestational age (SGA, n = 45), followed since birth (n = 76) or since the age of 3 years (n = 10). Assessments included anthropometry; fasting glucose and insulin; liver volume; and hepatic fat, subcutaneous fat, and visceral fat in the abdominal region (by magnetic resonance imaging [MRI]). RESULTS: Z-score change BW-BMI closely associated to central fat (R = 0.74; P
- Subjects :
- visceral fat
body mass index
insulin resistance
hepatic fat
birth weight
Subjects
Details
- ISSN :
- 20476310
- Database :
- OpenAIRE
- Journal :
- PEDIATRIC OBESITY, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
- Accession number :
- edsair.dedup.wf.001..093501ad78be07353f08ef3614b467ab