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A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

Authors :
Nijman, Ruud G
Oostenbrink, Rianne
Moll, Henriette A
Casals-Pascual, Climent
von Both, Ulrich
Cunnington, Aubrey
De, Tisham
Eleftheriou, Irini
Emonts, Marieke
Fink, Colin
van der Flier, Michiel
de Groot, Ronald
Kaforou, Myrsini
Kohlmaier, Benno
Kuijpers, Taco W
Lim, Emma
Maconochie, Ian K
Paulus, Stephane
Martinon-Torres, Federico
Pokorn, Marko
Romaine, Sam T
Calle, Irene Rivero
Schlapbach, Luregn J
Smit, Frank J
Tsolia, Maria
Usuf, Effua
Wright, Victoria J
Yeung, Shunmay
Zavadska, Dace
Zenz, Werner
Levin, Michael
Herberg, Jethro A
Carrol, Enitan D
PERFORM consortium (Personalized Risk assessment in febrile chil
Publication Year :
2021
Publisher :
Frontiers Media SA, 2021.

Abstract

Background: The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk of SBI. Methods: We used data from five previously published, prospective observational biomarker discovery studies, which included patients aged 0

Details

Language :
English
ISSN :
22962360
Database :
OpenAIRE
Accession number :
edsair.core.ac.uk....c8356d10050242922a5888a8ac0413c7