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Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin
- Publication Year :
- 2014
- Publisher :
- American Chemical Society, 2014.
-
Abstract
- Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.
- Subjects :
- Stroke
Glyco-magnetic nanoparticle
Nano-medicine
Selection
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 15306984 and 15306992
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....ae93c7a6bd04a33c5cd9aaad26646e90