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Genome-wide association study of germline variants and breast cancer-specific mortality
- Publication Year :
- 2019
- Publisher :
- Springer Nature, 2019.
-
Abstract
- BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P
Details
- Language :
- English
- ISSN :
- 00070920
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....83c0beb87469d32c17214d70d3a938d1