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CD4+CD3− Cells Induce Peyer's Patch Development Role of α4β1 Integrin Activation by CXCR5
- Source :
- Immunity. (3):363-373
- Publisher :
- Cell Press.
-
Abstract
- CD4+CD3− cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or α4β1 integrin-mediated adhesion. CXCR5−/− mice have CD4+CD3− cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates α4β1 integrin on CD4+CD3− cells. Blocking of β1 integrin or VCAM-1, the ligand of α4β1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation.
Details
- Language :
- English
- ISSN :
- 10747613
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.core.ac.uk....4633026382fcd8411294dd52331e511d
- Full Text :
- https://doi.org/10.1016/S1074-7613(02)00395-3