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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin- resistant Staphylococcus aureus: Blurring of the traditional definitions
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.
- Subjects :
- biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
Subjects
Details
- Language :
- English
- ISSN :
- 22137165
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....35c68ec1469d738975bd35e7304a2be9