Obstructive sleep apnea and objective sleep quality in non-dialysed patients with chronic kidney disease: an European Sleep Apnea Database (ESADA) study

BACKGROUND: Short sleep duration and poor sleep quality have been reported in chronic kidney disease (CKD). Additionally, sleep disordered breathing (SDB), a well-known cause of disturbed sleep, is highly prevalent in CKD. The majority of studies on sleep quality in CKD were focussed on dialysed patients, were based on subjective reports, and did not consider possible coexistence of SDB.1 Only a small number of studies assessed sleep quality on polysomnographic data in non-dialysed patients with CKD.2 AIM The aim of this study was to evaluate objective sleep quality based on electroencephalographic (EEG) recordings during nocturnal polysomnography in non-dialysed patients with CKD, taking into account coexisting SDB and psychiatric diagnoses. METHODS: The European Sleep Apnea Database (ESADA) cohort includes patients studied for suspected obstructive sleep apnea from numerous European sleep centres. From this cohort, 375 non-dialysed CKD patients who had undergone full polysomnography were matched one-by-one with 375 non-CKD patients. CKD was defined as an estimated glomerular filtration rate (eGFR) of