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Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis

Authors :
Matteucci C
Sorrentino R
Bellis L
Ettorre GM
Svicher V
Santoro R
Vennarecci G
Biasiolo A
Pontisso P
Scacciatelli D
Beneduce L
Sarrecchia C
Casalino P
Bernardini S
Pierimarchi P
Garaci E
Puoti C
Rasi G.
Source :
Hepatology research, (2013). doi:10.1111/hepr.12239, info:cnr-pdr/source/autori:Matteucci C, Sorrentino R, Bellis L, Ettorre GM, Svicher V, Santoro R, Vennarecci G, Biasiolo A, Pontisso P, Scacciatelli D, Beneduce L, Sarrecchia C, Casalino P, Bernardini S, Pierimarchi P, Garaci E, Puoti C, Rasi G./titolo:Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis./doi:10.1111%2Fhepr.12239/rivista:Hepatology research (Print)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume
Publication Year :
2013
Publisher :
Elsevier, Oxford ;, Paesi Bassi, 2013.

Abstract

AIM: The identification and surveillance of patients with liver dysfunctions and the discovering of new disease biomarkers with high sensibility and specificity are needed in the clinical practice. Aim of this study was to investigate on the serological presence of circulating Survivin-IgM immune complex (IC) as potential biomarker of diverse phases of chronic liver diseases. METHODS: Serum levels of Survivin-IgM were measured using an ELISA standardized and validated in our laboratory in 262 individuals, including healthy subjects and patients with chronic hepatitis, cirrhosis and HCC. RESULTS: Survivin-IgM IC was lower in healthy subjects (median: 99.39 AU/ml, IQR=73.33-148.27) than in patients with chronic viral hepatitis (median: 148.03 AU/ml, IQR=86.75-333.82; p=0.002) or with cirrhosis (median: 371.00 AU/ml, IQR=106.07-1110.06; p

Subjects

Subjects :
Survivin
Hepatocarcinoma Cirrosis
HCV

Details

Language :
English
Database :
OpenAIRE
Journal :
Hepatology research, (2013). doi:10.1111/hepr.12239, info:cnr-pdr/source/autori:Matteucci C, Sorrentino R, Bellis L, Ettorre GM, Svicher V, Santoro R, Vennarecci G, Biasiolo A, Pontisso P, Scacciatelli D, Beneduce L, Sarrecchia C, Casalino P, Bernardini S, Pierimarchi P, Garaci E, Puoti C, Rasi G./titolo:Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis./doi:10.1111%2Fhepr.12239/rivista:Hepatology research (Print)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume
Accession number :
edsair.cnr...........8474acf974f5530112c69cdd00fd6339

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