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Convenient preparation of (S)-fenoprofen by biocatalysed irreversible esterification
- Source :
- Rasayan journal of Chemistry 1 (2008): 732–737., info:cnr-pdr/source/autori:Morrone, R.; D'Antona, N.; Nicolosi, G./titolo:Convenient preparation of (S)-fenoprofen by biocatalysed irreversible esterification./doi:/rivista:Rasayan journal of Chemistry/anno:2008/pagina_da:732/pagina_a:737/intervallo_pagine:732–737/volume:1
- Publication Year :
- 2008
- Publisher :
- Pratima Sharma, Jaipur , India, 2008.
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Abstract
- Immobilised lipase B from Candida antarctica catalyzes the enantioselective esterification of rac-fenoprofen, (±)-1. The use of orthoformates as alcohol donors permitted to synthesize the ester in irreversible manner, therefore improving the performance of the enantioselective esterification. This convenient procedure permitted to prepare (S)-fenoprofen in good yield and in high optical purity.
- Subjects :
- Irreversible esterification
Fenoprofen
Lipase
Orthoformates
NSAID
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Rasayan journal of Chemistry 1 (2008): 732–737., info:cnr-pdr/source/autori:Morrone, R.; D'Antona, N.; Nicolosi, G./titolo:Convenient preparation of (S)-fenoprofen by biocatalysed irreversible esterification./doi:/rivista:Rasayan journal of Chemistry/anno:2008/pagina_da:732/pagina_a:737/intervallo_pagine:732–737/volume:1
- Accession number :
- edsair.cnr...........70f45655a9ec5202c7df99003cc0ca9a