Back to Search
Start Over
Collisionally induced fragmentation of [M-H](-) species of resveratrol and piceatannol investigated by deuterium labelling and accurate mass measurements
- Source :
- RCM. Rapid communications in mass spectrometry 22 (2008): 3867–3872., info:cnr-pdr/source/autori:Stella, L.; De Rosso, M.; Panighel, A.; Vedova, A. D.; Flamini, R.; Traldi, P./titolo:Collisionally induced fragmentation of [M-H](-) species of resveratrol and piceatannol investigated by deuterium labelling and accurate mass measurements/doi:/rivista:RCM. Rapid communications in mass spectrometry/anno:2008/pagina_da:3867/pagina_a:3872/intervallo_pagine:3867–3872/volume:22
- Publication Year :
- 2008
- Publisher :
- Heyden, London , Regno Unito, 2008.
-
Abstract
- Resveratrol (3,5,4'-trihydroxystilbene) and piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) are phytoalexins present in red grapes and wines. In vitro studies have revealed that piceatannol blocks LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with the Epstein-Barr virus, and has an antimelanoma effect on human melanoma cells. Resveratrol has several beneficial effects on human health, such as anticancer, cardioprotection, antioxidant, inhibition of platelet aggregation and anti-inflammatory activity. In this investigation, the collisional behaviour of deprotonated resveratrol and piceatannol obtained under electrospray conditions is described. The mechanisms involved in the fragmentation pattern of [M-H](-) species of the two compounds were investigated by performing MSn experiments, deuterium labelling and accurate mass measurements. Copyright (C) 2008 John Wiley & Sons, Ltd.
Details
- Database :
- OpenAIRE
- Journal :
- RCM. Rapid communications in mass spectrometry 22 (2008): 3867–3872., info:cnr-pdr/source/autori:Stella, L.; De Rosso, M.; Panighel, A.; Vedova, A. D.; Flamini, R.; Traldi, P./titolo:Collisionally induced fragmentation of [M-H](-) species of resveratrol and piceatannol investigated by deuterium labelling and accurate mass measurements/doi:/rivista:RCM. Rapid communications in mass spectrometry/anno:2008/pagina_da:3867/pagina_a:3872/intervallo_pagine:3867–3872/volume:22
- Accession number :
- edsair.cnr...........3066fd32f3c8875688f74e112cc5abaa