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Metastatic Colorectal Cancer. First Line Therapy for Unresectable Disease

Authors :
Aparicio J
Esposito F
Serrano S
Falco E
Escudero P
Ruiz-Casado A
Manzano H
Fernandez-Montes A
Source :
Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Colorectal cancer (CRC) is a commonly diagnosed malignancy. The prognosis of patients with unresectable, metastatic colorectal cancer (mCRC) is dismal and medical treatment is mainly palliative in nature. Although chemotherapy remains the backbone of treatment, the landscape is changing with the understanding of its heterogeneity and molecular biology. First-line therapy relies on a combination of chemotherapy and targeted therapies, according to clinical patient characteristics and tumor molecular profile. Here we review current evidence from randomized clinical trials for using chemotherapy doublets or triplets, and for the addition of bevacizumab or anti-epidermal growth factor receptor (EGFR) agents. Novel therapies developed for small, selected populations are also discussed.

Details

ISSN :
20770383
Database :
OpenAIRE
Journal :
Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Accession number :
edsair.RECOLECTA.....b3d888f676182ce78c5e27f06babd023