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Bone: A new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders
- Source :
- Lancet Diabetes & Endocrinology, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname
- Publication Year :
- 2014
- Publisher :
- ELSEVIER SCIENCE INC, 2014.
-
Abstract
- Recent reports of several bone-derived substances, some of which have hormonal properties, have shed new light on the bone-cardiovascular axis. Deranged concentrations of humoral factors are not only epidemiologically connected to cardiovascular morbidity and mortality, but can also be causally implicated, especially in chronic kidney disease. FGF23 rises exponentially with advancing chronic kidney disease, seems to reach maladaptive concentrations, and then induces left ventricular hypertrophy, and is possibly implicated in the process of vessel calcification. Sclerostin and DKK1, both secreted mainly by osteocytes, are important Wnt inhibitors and as such can interfere with systems for biological signalling that operate in the vessel wall. Osteocalcin, produced by osteoblasts or released from mineralised bone, interferes with insulin concentrations and sensitivity, and its metabolism is disturbed in kidney disease. These bone-derived humoral factors might place the bone at the centre of cardiovascular disease associated with chronic kidney disease. Most importantly, factors that dictate the regulation of these substances in bone and subsequent secretion into the circulation have not been researched, and could provide entirely new avenues for therapeutic intervention. © 2014 Elsevier Ltd.
- Subjects :
- mineral
SOST protein, human
protein alpha Klotho
kidney disease
bone tissue
sclerostin
Review
bone
cardiovascular disease
bone morphogenetic protein
energy metabolism
ris
dickkopf 1 protein
randomized controlled trial (topic)
vitamin K group
protein function
farnoquinone
Klotho protein
unclassified drug
priority journal
bone mineral
genetic marker
cardiovascular risk
insulin
osteocalcin
bone morphogenetic protein 2
DKK1 protein, human
fibroblast growth factor 23
Wnt signaling pathway
osteogenic protein 1
postmenopause osteoporosis
heart left ventricle hypertrophy
fibroblast growth factor
protein secretion
insulin sensitivity
signal peptide
human
protein expression
blood vessel calcification
romosozumab
nonhuman
disease association
Wnt protein
osteoporosis
ossification
bone disease
metabolic regulation
bone metabolism
atherosclerosis
chronic kidney disease
Subjects
Details
- ISSN :
- 22138587
- Database :
- OpenAIRE
- Journal :
- Lancet Diabetes & Endocrinology, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname
- Accession number :
- edsair.RECOLECTA.....aa5e4d25888b224a23f546f2a9413a16