Genomic analysis of high-risk smoldering multiple myeloma

Authors :: López-Corral L
Mateos MV
Corchete LA
Sarasquete ME
de la Rubia J
de Arriba F
Lahuerta JJ
García-Sanz R
San Miguel JF
Gutiérrez NC
Source :: HAEMATOLOGICA, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Publication Year :: 2012
Publisher :: FERRATA STORTI FOUNDATION, 2012.
Abstract: Smoldering myeloma is an asymptomatic plasma cell dyscrasia with a heterogeneous propensity to progress to active myeloma. In order to investigate the biology of smoldering myeloma patients with high risk of progression, we analyzed the genomic characteristics by FISH, SNP-arrays and gene expression profile of a group of patients with high-risk smoldering myeloma included in a multicenter randomized trial. Chromosomal abnormalities detected by FISH and SNP-arrays at diagnosis were not associated to risk of progression to symptomatic myeloma. However, the overexpression of four SNORD genes (SNORD25, SNORD27, SNORD30 and SNORD31) was correlated with shorter time to progression (P

ISSN :: 03906078
Database :: OpenAIRE
Journal :: HAEMATOLOGICA, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Accession number :: edsair.RECOLECTA.....4f60826d2fd2b43ec0f62ba4b3d19ee9

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