In vitro methaemoglobin reducing potential of crude methanolic extract and fractions of Sterculiasetigera leaf on human sickled red blood cells

Sickle cell anaemia is a hereditary disease affecting the red blood cells as a result of acquisition of a mutant β-globin gene, one from each parent. One of the pathophysiology of sickle cell anaemia is abnormally high concentration of methaemoglobin in the circulating red blood cells. Treatments for sickle cell anaemia are complex and expensive, Hence, cheap alternative remedies have to be identified. This study evaluated the percentage methaemoglobin concentration of sodium metabisulphite sickled erythrocytes in the presence of methanolic extract and fractions of Sterculia setigera leaf at concentrations of 0.2mg/ml, 0.4mg/ml, 0.6mg/ml, 0.8mg/ml, and 1mg/ml which showed that a significant (p