Therapeutic drug monitoring of mycophenolic acid in patients with kidney transplant

Authors :: Puretić, Zvonimir
Granić, Paula
Bubić-Filipi, Ljubica
Lalić, Zdenka
Lovrić, Mila
Humar, Ines
Mustapić, Željka
Sertić, Jadranka
Kes, Petar
Banfić H., Boban M., Francetić I., Klarica M., Mück-Šeler D., Pivac N., Sabolić I., Tvrdeić A., Župan G.
Publication Year :: 2007
Abstract: Mycophenolate mofetil (MMF) is an immunosupressive drug used in prophylaxis of rejection of transplanted solid organs in combination with cyclosporine A (CyA) and steroids. It is metabolised in the liver to the active component mycophenolic acid (MPA), an irreversible noncompetitive inhibitor of cell enzime 5'-monophosphate (IMP)dehydrogenase. The aim of the study was...

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