Synchronous skin carcinomas analysed by immunohistochemistry and laser capture microdissection followed by PCR for HPV

Synchronous appearance of 2 or more different malignancies in the same patient is rare incident. Present case describes a 76-year-old immunodeficient woman with synchronous primary cutaneous malignancies, one on the fourth finger, and another on dorsum of the same hand. Pathohistological and immunohistochemical examination showed two different malignant cutaneous tumors, i.e. poorly differentiated sarcomatoid squamous cell carcinoma (positive for vimentin, EMA and CK 5/6) and basal cell carcinoma (positive for bcl-2, while negative for vimentin, EMA and CK 5/6). In addition, p53 was positive in approximately 50%of all tumors cells of squamous cell carcinoma while in basal cell carcinoma almost all cells expressed this protein....