Consumption of white wine decreases expression of inflammatory markers following myocardial infarction in rats

Introduction: The aim of our study was to investigate the effect of white wine consumption on the expression of early inflammatory markers (MMP-2, MMP-9, NF-B) in the myocardial tissue following experimentally induced permanent myocardial ischemia. Materials and methods: Male Sprague-dawley rats (n=10) were randomized into two groups: drinking a combination of wine and water and those drinking water only for 28 days. After performing the coronary ligation, animals were left to survive for 24 hours and then sacrificed. Three representative zones for each group of animals: infarct/ischemic, periinfarct/ border zone and control/nonischemic zones were analysed for the expression of immunoreactivity for the above markers. The threshold area % of signal density for each marker was measured and compared. Results: For MMP-9, a significantly smaller expression was found in all three zones of wine drinking animals group (p