Overview of ferrocene peptidomimetics – conformational analysis, DFT study and solid state

The biological activity, conformational stability, and therapeutic application of peptides depend on their secondary structure. Therefore, the main goal in the design and preparation of synthetic peptides is to nucleate the formation of secondary structure elements. It has been shown that various ferrocene templates, when incorporated into peptides, induce the formation of hydrogen bonds, which allows the formation of turn- and -sheet- like structures [1, 2]. Here, we provide an overview of hydrogen-bonding patterns in ferrocene peptides based on detailed spectroscopic, DFT and crystallographic analyses.