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Identification of cross-reactive and genuine Parietaria judaica pollen allergens
- Source :
- The Journal of Allergy and Clinical Immunology; May 2003, Vol. 111 Issue: 5 p974-979, 6p
- Publication Year :
- 2003
-
Abstract
- Background:: The weed Parietaria judaica is one of the most important pollen allergen sources in the Mediterranean area. Objective:: We sought to identify P judaica pollen allergen, which might be used to serologically distinguish genuine Parietaria sensitization and cross-reactivity to allergens from other weed species (eg, mugwort and ragweed). Methods:: The allergen profile of P judaica IgE-reactive sera from weed pollen-sensitized allergic individuals from the Mediterranean region (n=36) with high Parietaria pollen exposure and from weed pollen-allergic patients with little or no Parietaria exposure (Austria, n=42; Scandinavia, n=8; United States, n=19) was established by CAP FEIA measurements and by IgE immunoblot inhibition experiments with recombinant allergens. Results:: The majority (83%) of the Mediterranean weed pollen-allergic patients mounted high IgE antibody levels (mean specific IgE, 20.89 kUA/L) against recombinant (r) Par j 2, whereas only 7% of the non-Mediterranean weed-allergic patients showed low IgE reactivity to rPar j 2 (mean specific IgE, 1.03 kUA/L). The cytoskeletal protein profilin and a 2-EF-hand calcium-binding allergen were identified as cross-reactive Parietaria allergens, which were recognized preferentially by Parietaria-positive, non-Mediterranean weed pollen-allergic patients. Conclusion:: rPar j 2 might be used as a diagnostic marker allergen to identify weed pollen-allergic patients who are genuinely sensitized against Parietaria pollen and thus would be particularly suited for specific immunotherapy with Parietaria pollen extract.
Details
- Language :
- English
- ISSN :
- 00916749 and 10976825
- Volume :
- 111
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- The Journal of Allergy and Clinical Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs9864221
- Full Text :
- https://doi.org/10.1016/S0091-6749(03)80123-9