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Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B1 Receptor Antagonists
- Source :
- Journal of Medicinal Chemistry; February 2006, Vol. 49 Issue: 4 p1231-1234, 4p
- Publication Year :
- 2006
-
Abstract
- Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and good bioavailability in the rat.
Details
- Language :
- English
- ISSN :
- 00222623 and 15204804
- Volume :
- 49
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs8836987
- Full Text :
- https://doi.org/10.1021/jm0511280