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Stereoselective Synthesis of Axially Chiral N−C Bonds in N-Aryl Indoles

Authors :
Kamikawa, Ken
Kinoshita, Shunsuke
Matsuzaka, Hiroyuki
Uemura, Motokazu
Source :
Organic Letters; March 2006, Vol. 8 Issue: 6 p1097-1100, 4p
Publication Year :
2006

Abstract

N-Aryl indoles with axially chiral N−C bonds were synthesized by stereoselective nucleophilic aromatic substitution reactions of planar chiral arene chromium complexes. Stereoselective chromium tricarbonyl migration was achieved in the sterically hindered N-aryl indole chromium complex by refluxing in toluene.

Details

Language :
English
ISSN :
15237060 and 15237052
Volume :
8
Issue :
6
Database :
Supplemental Index
Journal :
Organic Letters
Publication Type :
Periodical
Accession number :
ejs8709226
Full Text :
https://doi.org/10.1021/ol0529997