THE EFFECT OF CHOLINERGIC ENHANCEMENT DURING FILLING CYSTOMETRY: CAN EDROPHONIUM CHLORIDE BE USED AS A PROVOCATIVE TEST FOR OVERACTIVE BLADDER?

Overactive bladder, a highly prevalent disorder, is suspected of having a low detection rate due to the lack of sensitive diagnostic tools. Recent studies imply the involvement of the cholinergic system in the pathophysiological mechanism underlying overactive bladder. We determined whether in vivo enhancement of cholinergic activity with edrophonium chloride, a potent cholinesterase inhibitor, would serve as a provocative maneuver to increase the sensitivity of filling cystometry.